Electrochemistry and analytical determination of lysergic acid diethylamide (LSD) via adsorptive stripping voltammetry
Daniele Merli, Daniele Zamboni, Stefano Protti, Maria Pesavento, Antonella Profumo
Talanta July 22, 2014 DOI: 10.1016/j.talanta.2014.07.037 via OpenAlex
Summary
AI-generated from the abstractA simple and accurate method for measuring lysergic acid diethylamide (LSD) in biological samples uses adsorptive stripping voltammetry in DMF/tetrabutylammonium perchlorate. The method detects LSD at very low concentrations, with a linear range of 1-90 ng L(-1) for 50-second deposition times, a limit of detection of 1.4 ng L(-1), and a limit of quantification of 4.3 ng L(-1). It can be applied to biological samples after a simple extraction with 1-chlorobutane, enabling routine analysis of LSD, which is otherwise difficult to detect due to its low active dose.
Study at a glance
| Characteristics | Method development and validation Peer reviewed |
|---|---|
| Keywords | Chromatography Adsorptive stripping voltammetry Stripping fiber Extraction chemistry Perchlorate |
| Citations | 36 |
| Key finding | A voltammetric method can detect LSD at concentrations as low as 1.4 ng L(-1) and quantify it at 4.3 ng L(-1) in biological samples after extraction. |
Abstract
Lysergic acid diethylamide (LSD) is hardly detectable and quantifiable in biological samples because of its low active dose. Although several analytical tests are available, routine analysis of this drug is rarely performed. In this article, we report a simple and accurate method for the determination of LSD, based on adsorptive stripping voltammetry in DMF/tetrabutylammonium perchlorate, with a linear range of 1-90 ng L(-1) for deposition times of 50s. LOD of 1.4 ng L(-1) and LOQ of 4.3 ng L(-1) were found. The method can be also applied to biological samples after a simple extraction with 1-chlorobutane.