In Vivo and in Vitro Chromosomal Damage Induced by LSD-25
Maimon M. Cohen, Kurt Hirschhorn, William A. Frosch
New England Journal of Medicine November 16, 1967 DOI: 10.1056/nejm196711162772001 via OpenAlex
Summary
AI-generated from the abstractLysergic acid diethylamide (LSD-25) can cause chromosomal abnormalities in human leukocytes, as shown by in vitro and in vivo studies. This report extends earlier observations with additional in vitro findings and a larger sample of patients. The study examined peripheral leukocyte cultures from six healthy individuals to assess chromosomal aberrations induced by LSD.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 6 |
| Population | Normal, healthy persons (3 males and 3 females) |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | In vitro In vivo Psychotomimetic Hallucinogen |
| Citations | 150 |
| Key finding | LSD-25 induces chromosomal aberrations in human leukocytes. |
Abstract
THE induction of chromosomal aberrations by exogenous agents, such as viruses, radiation and chemicals, is an area of active cytogenetic investigation.1 Recently, the psychotomimetic hallucinogen, lysergic acid diethylamide (LSD-25), has been added to the list of chemicals capable of causing abnormalities in the chromosomes of human leukocytes.2 , 3 Such preliminary studies report the in vitro and in vivo chromosomal effects of LSD, and the present communication extends these observations to include additional in vitro findings and a significant sample of patients.Materials and MethodsIn Vitro StudiesPeripheral leukocyte cultures were initiated from 6 normal, healthy persons (3 males and 3 . . .