Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and‡ 9-THC using the micronucleus test
Cellular and Molecular Life Sciences March 1, 1978 DOI: 10.1007/bf01923013 via OpenAlex
Summary
AI-generated from the abstractNo significant increase in micronuclei—a marker of genetic damage—was observed in mice given three logarithmically increasing doses of LSD, psilocybin, or delta-9-THC. Azathioprine (Imuran), used as a positive control, caused a statistically significant increase in micronucleated cells. These results suggest that, under the conditions tested, these compounds did not induce detectable mutagenic activity in the micronucleus assay.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | LSD psilocybin delta-9-THC |
| Dose | 3 logarithmically increasing doses |
| Topics | Psilocybin |
| Keywords | Hallucinogen Micronucleus test Pharmacology Chemistry |
| Citations | 43 |
| Key finding | LSD, psilocybin, and delta-9-THC did not cause a significant increase in micronuclei in mice, while azathioprine did. |
Abstract
Using the micronucleus test as a screening method for mutagenic activity, no significant increase in the number of micronuclei was found when LSD, psilocybin or delta 9-THC were administered in 3 logarithmically increasing doses to mice, Azathioiprine (Imuran), given as a positive control, caused a statistically significantt increase in the micronucleated cells.