LSD 5-HT2A receptor occupancy and global functional connectivity effects
Figshare January 1, 2026 DOI: 10.6084/m9.figshare.31073185.v1 via OpenAlex
Summary
AI-generated from the abstractLSD occupies the serotonin 2A receptor (5-HT2AR) and alters global functional connectivity in healthy human participants. The figure shows occupancy and connectivity effects for both LSD and psilocybin. Acquisition, preprocessing, and statistical modeling procedures were pre-registered and detailed in a study protocol.
Study at a glance
| Characteristics | Pre-registered protocol Preregistered Peer reviewed |
|---|---|
| Population | Healthy human participants |
| Interventions | LSD psilocybin |
| Topics | Serotonin |
| Keywords | Occupancy Functional connectivity Receptor Protocol science |
| Key finding | LSD occupies the serotonin 2A receptor and alters global functional connectivity in healthy humans. |
Abstract
This figure presents LSD occupancy at the serotonin 2A receptor (5-HT2AR) and global functional connectivity effects in healthy human participants for LSD and psilocybin. PET and fMRI acquisition, preprocessing, and statistical modelling procedures were pre-registered and are described in detail in the study protocol available on medRxiv (https://doi.org/10.1101/2025.06.17.25329677).