Correction: Dissociable effects of psilocybin and escitalopram for depression on processing of musical surprises.
Rebecca Harding, Neomi Singer, Matthew B. Wall, Talma Hendler, David Erritzøe, David Nutt, Robin Carhart-Harris, Leor Roseman
Mol Psychiatry July 1, 2025 correction DOI: 10.1038/s41380-025-03066-1 via PubMed Central
Summary
AI-generated from the abstractIn a study comparing psilocybin therapy (PT) to escitalopram for depression, brain responses to unexpected musical notes were measured. After PT, there was decreased activation in the ventromedial prefrontal cortex and angular gyrus, and greater activation in sensory regions. This suggests PT alters brain processing of unexpected events differently than escitalopram, potentially contributing to its therapeutic effects.
Study at a glance
| Characteristics | Randomized controlled trial |
|---|---|
| Topics | Psilocybin Psychedelic-assisted therapy |
| Keywords | Depression treatment Mood improvement Mental health therapy Psychiatric treatment Therapeutic mechanisms |
| Key finding | Psilocybin therapy decreased activation in the ventromedial prefrontal cortex and angular gyrus while increasing activation in sensory regions during processing of unexpected musical notes. |
Abstract
The following part of the abstract had a minor error: ‘Following PT, there was greater activation in the ventromedial prefrontal cortex and sensory regions, and reduced activation in the angular gyrus.’ This is now corrected to ‘Following PT, there was decreased activation in the ventromedial prefrontal cortex and angular gyrus, and greater activation in sensory regions.’ The original article has been updated accordingly.