Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.
R A Glennon, R Young, F Benington, R D Morin
Life sciences February 1, 1982 DOI: 10.1016/0024-3205(82)90463-5 via PubMed
Summary
AI-generated from the abstractRats trained to distinguish the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a drug discrimination task were tested with three related compounds: the 4-methoxy, 4-methylthio, and 5-methylthio derivatives of DMT. All three derivatives produced effects similar to the original drug. The relative potency of the compounds, from most to least potent, was 5-OMe DMT, followed by 5-SMe DMT, then 4-OMe DMT, and finally 4-SMe DMT.
Study at a glance
| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-methoxy-N N-dimethyltryptamine |
| Dose | 1.5 mg/kg |
| Citations | 8 |
| Key finding | The 5-OMe DMT cue generalized to the 4-methoxy, 4-methylthio, and 5-methylthio derivatives of DMT, with potency ranking 5-OMe > 5-SMe > 4-OMe > 4-SMe DMT. |
Abstract
Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all three of these agents; the order of potency is 5-OMe greater than 5-SMe greater than 4-OMe greater than 4-SMe DMT.