Ascorbic acid antagonizes the behavioural effects of LSD in cats.
M E Trulson, T Crisp, L J Henderson
The Journal of pharmacy and pharmacology December 1, 1985 DOI: 10.1111/j.2042-7158.1985.tb05009.x via PubMed
Summary
AI-generated from the abstractGiving cats ascorbic acid before LSD or apomorphine blocked certain behavioral effects, but it did not block the effects of 5-methoxy-N,N-dimethyltryptamine. These results suggest that the behaviors caused by LSD and apomorphine involve both serotonin and dopamine receptors, and that ascorbic acid can change how LSD acts at dopamine receptors.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cats |
| Intervention | ascorbic acid |
| Dose | 500 mg kg-1 i.p. |
| Key finding | Pretreatment with ascorbic acid antagonized the behavioral effects of LSD and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. |
Abstract
Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that these behavioural effects in cats are due to drug action at both 5-HT and dopamine receptors, and that the action of LSD at dopamine receptors is modulated by ascorbic acid.