Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats.
T Nabeshima, K Ishikawa, K Yamaguchi, H Furukawa, T Kameyama
Neuroscience letters May 19, 1987 DOI: 10.1016/0304-3940(87)90425-3 via PubMed
Summary
AI-generated from the abstractPhencyclidine (PCP) causes a head-twitch response in mice and rats that is completely blocked by ritanserin, a serotonin 5-HT2 receptor antagonist, indicating the involvement of 5-HT2 receptors. The same antagonism occurs for head-twitch induced by 5-MeODMT in mice. After ritanserin treatment, PCP and 5-MeODMT still produce head-weaving in mice but not in rats. In rats, 5-MeODMT does not cause head-twitch. These results suggest that PCP-induced head-twitch in rats is mediated by 5-HT2 receptors, making it a useful model for studying those receptors, while 5-MeODMT-induced head-weaving in rats involves 5-HT1 receptors.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice and rats |
| Interventions | Phencyclidine (PCP) 5-methoxy-N N-dimethyltryptamine (5-MeODMT) ritanserin |
| Dose | PCP 7.5, 10 and 12.5 mg/kg i.p.; 5-MeODMT 2 and 4 mg/kg i.p.; ritanserin 1 mg/kg s.c. |
| Citations | 27 |
| Key finding | PCP-induced head-twitch is mediated by 5-HT2 receptors, as it is completely antagonized by ritanserin in both mice and rats. |
Abstract
This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg, i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.