Fatal toxic leukoencephalopathy secondary to overdose of a new psychoactive designer drug 2C-E ("Europa").

A fatal case of toxic leukoencephalopathy occurred after someone ingested the new psychoactive designer drug 2C-E, also called "Europa." Recreational hallucinogenic drugs are growing in popularity, partly because information and newer designer substances are easily available online without legal consequences. Magnetic resonance imaging (MRI) showed selective diffuse toxic injury to the cerebral white matter, while the cortex and most deep gray nuclei were spared. This is the first reported description of MRI findings likely related to a lethal ingestion of 2C-E.

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Abstract

We present a case of a fatal toxic leukoencephalopathy following ingestion of a new psychoactive designer drug known as 2C-E or "Europa." Recreational drugs, particularly hallucinogenic substances, appear to be growing in popularity, with increasing amounts of information available via the Internet to entice potential users. In addition, some newer "designer" psychoactive substances are available for purchase online without adverse legal consequences, therefore adding to their popularity. We describe magnetic resonance imaging (MRI) findings to include selective diffuse toxic injury of the cerebral white matter with sparing of the cortex and most of the deep gray nuclei. To our knowledge, this is the first reported description of cerebral findings on MRI that are likely related to a lethal ingestion of 2C-E.