Psychedelics in Practice: Science, Safety, and the Future of Healing
PROCEEDINGS OF THE SLIIT INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN SCIENCES AND HUMANITIES [SICASH] October 10, 2025 Renee Ireland
Psychedelic-assisted therapies are re-emerging as credible options in psychological care, addressing the high global burden of mental ill-health and limited response to first-line treatments. Classic and atypical compounds like psilocybin and MDMA act through 5-HT2A-mediated effects, default mode network modulation, increased global connectivity, and a time-limited neuroplasticity window that psychotherapy can harness. Evidence supports applications for treatment-resistant depression, PTSD, end-of-life anxiety, and addictions. Positive outcomes depend on the therapeutic frame—preparation, supported dosing, and structured integration—not medication alone. Risks, contraindications, regulatory realities, and cultural-ethical considerations, including Indigenous knowledge and equity of access, are addressed.