Effect of duloxetine acute treatment against 3, 4 methylenedioxymethamphetamine-induced cognitive impairment and memory deficiency in male rats
Avicenna Journal of Neuro Psycho Physiology June 22, 2020
In male rats, MDMA reduced anxiety, as shown by more time in the open arms of an elevated plus maze, and impaired learning and memory, indicated by more time in the dark compartment of a passive avoidance test and longer swimming time to a platform in a Morris water maze. Duloxetine, an antidepressant, counteracted these effects: it reversed MDMA-induced reductions in object discrimination, reduced time in the dark compartment, and improved platform finding. Duloxetine also decreased time in open arms and target quadrant, suggesting it attenuated MDMA's anxiolytic effect and improved cognitive and memory disturbances.