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Our Love Affair with Drugs

2 papers in the library · publishing 2020

Papers

Methylenedioxymethamphetamine (MDMA)a.k.a. Ecstasy

Our Love Affair with Drugs October 1, 2020 Jerrold Winter

MDMA is currently a Schedule I drug with no accepted medical use, high abuse potential, and no accepted safety even under medical supervision. However, the FDA has designated MDMA-assisted psychotherapy as a breakthrough therapy, and the drug may eventually be available by prescription. The recreational drug Ecstasy often differs from pure MDMA: an analysis of 1,214 tablets sold as Ecstasy found only 39% contained only MDMA, 46% were substances other than MDMA, and 15% were mixtures. Street-bought Ecstasy may contain ketamine, GHB, cathinone, ephedrine, caffeine, or designer drugs, leading to hazards being incorrectly attributed to MDMA. In clinical trials, MDMA is FDA-approved and of known composition.

Dissociative Anesthetics: Angel Dust to Special K to Ketamine Clinics

Our Love Affair with Drugs January 10, 2020 J. Winter

Phencyclidine (PCP) and ketamine are anesthetic agents with unique pharmacological properties, distinct from depressant drugs, as they produce anesthesia without suppressing breathing. PCP was synthesized in 1956 and tested in animals, showing effects ranging from excitement to quieting and analgesia. Human studies began in 1957 at Detroit Receiving Hospital, first in seven volunteers, then in 64 patients aged 18 to 78 (47 women) undergoing surgeries like breast biopsy and hysterectomy. Intravenous PCP provided profound analgesia, often allowing surgery without additional drugs.