Psilocybe Poisoning: Pathophysiology, Classification and Treatment. A Clinical Case Review
Mexican Journal of Medical Research ICSA July 5, 2026 Omar Azuara-Antonio, Erika Rubí de la Cruz-Elizaldeb, José Eduardo Carmona-Rodriguez et al.
Psilocybe cubensis mushrooms are the primary natural source of psilocybin in the Americas and have a long history of use in Mesoamerican rituals for inducing altered states of consciousness. After ingestion, psilocybin is metabolized into psilocin, a potent serotonergic agonist acting on 5-HT receptors and releasing glutamate. The Aztecs called them Teonanácatl, or 'flesh of the gods.' Interest revived with R. Gordon Wasson's 1950s ethnobotany and now includes research on therapeutic applications for depression, suggesting sustainable relief with fewer side effects than conventional treatments. This combination of ancient ceremonial use and therapeutic potential is prompting reevaluation of their Schedule I legal status, with promising results for major depressive disorder and other psychiatric conditions.