Rapid Communications in Mass Spectrometry
February 20, 2008
Ya‐hsueh Wu, Keh‐liang Lin, Su‐chin Chen et al.
69 citations
A gas chromatography/mass spectrometry method was developed and validated to simultaneously quantify amphetamines, ketamine, and opiates in human hair samples. Hair specimens (25 mg) were washed, cut, incubated in methanol/trifluoroacetic acid, extracted by solid-phase extraction, and derivatized before analysis. Calibration curves for ten analytes were linear from 0.1 to 10 ng/mg with correlation coefficients above 0.999. Detection limits ranged from 0.03 to 0.08 ng/mg, and quantification limits from 0.05 to 0.1 ng/mg. Recoveries exceeded 88.6% for all compounds except ketamine and norketamine (71.7–72.7%). Testing eight hair samples from known polydrug abusers demonstrated the method's suitability for broad-spectrum drug testing in a single hair specimen.
Rapid Communications in Mass Spectrometry
May 1, 2007
Jin Young Kim, Kyu Sung Jung, Min Kyoung Kim et al.
48 citations
A gas chromatography/mass spectrometric method was developed and validated to measure thirteen psychotropic phenylalkylamine derivatives in human hair. Hair samples were washed, cut, and incubated in methanolic HCl, then derivatized with trifluoroacetic anhydride and analyzed. The method showed linear ranges from 0.02 to 25.0 ng/mg for most compounds, with good correlation coefficients above 0.9985. Precisions were within 16.8%, accuracies between −15.3 and 13.4%, and recoveries from 76.7 to 95.6%. Limits of quantification were below 0.08 ng/mg. The method is suitable for simultaneous qualification and quantification of these compounds in hair.
Rapid Communications in Mass Spectrometry
February 11, 2005
Ti‐yu Wu, Ming‐ren Fuh
43 citations
A fully automated method using online solid-phase extraction and ion-pairing liquid chromatography with electrospray tandem mass spectrometry was developed to measure amphetamine, methamphetamine, MDA, MDEA, and MDMA in urine. Recoveries ranged from 85 to 101%. Linear ranges were 10–500 ng/mL for amphetamine and methamphetamine, and dual linear ranges of 5–100 and 100–500 ng/mL for MDA, MDMA, and MDEA. Detection limits were 1–3 ng/mL. Testing on urine samples from drug users showed good agreement with an established GC/MS method.
Rapid Communications in Mass Spectrometry
January 1, 1993
Nicholas P. Bukowski, Andrew N. Eaton
11 citations
A method using gas chromatography/mass spectrometry confirms and measures LSD as its trimethylsilyl derivative. It requires four times less sample than earlier approaches, extends column life by reducing the amount of derivatizing agent, and can detect and quantify LSD at concentrations as low as 10 pg/mL.