World Journal of Psychiatry
May 19, 2023
Lakshan N Fonseka, Benjamin K.p. Woo
12 citations
Psilocybin and MDMA, designated breakthrough therapies by the FDA in 2017 for post-traumatic stress disorder and treatment-resistant depression, are being studied for rapid improvement in psychiatric conditions. Classic psychedelics like psilocybin, LSD, and ayahuasca, along with non-classic drugs such as MDMA and ketamine, show potential for treating trauma and depressive disorders. This review focuses on psilocybin and MDMA in psychedelic-assisted therapy (PAT), as they compose most of the literature. It discusses their current and future uses, emphasizing their role in trauma and related comorbidities, and suggests future research directions including wearables, standardized symptom scales, therapy styles, and adverse drug reaction assessment.
World Journal of Psychiatry
June 26, 2026
Jia-zhao Zhang, Tian-Tian Wang, Jing Zhang et al.
Schizophrenia involves marked abnormalities in consciousness, particularly in the interplay between implicit and explicit cognitive processing. Evidence from visual masking and mismatch negativity paradigms indicates deficits from preattentive stages to conscious access. Metacognitive impairments in error and source monitoring suggest implicit processing fails to achieve stable explicit representation. These abnormalities are linked to predictive coding errors, thalamocortical dysconnectivity, and aberrant neural synchrony. This framework connects micro-level sensory deficits with macro-level psychotic phenomenology and may guide future transdiagnostic neuromodulatory interventions.
World Journal of Psychiatry
April 19, 2025
Hasan Belli
Dissociative psychosis and dissociative schizophrenia are clinical concepts that may offer new perspectives on mental disorders. Research has not demonstrated a clear and valid relationship between dissociation, childhood traumatic experiences, and schizophrenia or psychotic spectrum disorders, though some statistical comparisons support the existence of these clinical manifestations. Dissociation, childhood traumatic experiences, and positive psychotic symptoms may be prominent in dissociative psychosis and schizophrenia, while intense negative symptoms may indicate classical schizophrenia. Psychometric tests can help detect dissociative psychosis symptoms. Psychotic individuals with traumatic experiences may benefit from trauma-focused treatment.