Naunyn Schmiedebergs Arch Pharmacol

ISSN 0028-1298; 1432-1912;

2 papers in the library · 24 citations · publishing 2016-2026

Papers

Neurochemical binding profiles of novel indole and benzofuran MDMA analogues.

Naunyn Schmiedebergs Arch Pharmacol September 20, 2016 Jakob A. Shimshoni, Ilan Winkler, Ezekiel Golan et al. 23 citations

Four MDMA analogues—three benzofuran compounds (5-APB, 6-MAPB, 5-MAPB) and one indole compound (5-IT)—were screened as potential second-generation drugs for PTSD. All analogues showed high binding affinities for serotonin 5-HT2a,b,c and norepinephrine α2 receptors, and significantly inhibited serotonin, dopamine, and norepinephrine uptake. 5-APB acted as an agonist at all three 5-HT2 receptor subtypes, while 6-MAPB, 5-MAPB, and 5-IT were agonists at the 5-HT2c receptor. The analogues also emerged as potent and selective inhibitors of monoamine oxidase A. 6-MAPB, with a favorable pharmacological profile, was further tested for its potency at monoamine transporters. Overall, the analogues displayed higher binding affinities and greater agonist activity at 5-HT2a,c receptors compared to MDMA.

DOI: 10.1007/s00210-016-1297-4 Novel compounds Indole analogues Benzofuran analogues New compounds +29

Adverse drug events and toxicological mechanisms of esketamine: a study based on US Food and Drug Administration Adverse Event Reporting System and network toxicology analysis.

Naunyn Schmiedebergs Arch Pharmacol February 26, 2026 Lu Wang, Rui Xiong, Hengxu Liu et al. 1 citation

Esketamine, a drug used for treatment-resistant depression, is associated with a range of adverse drug events, including psychiatric, neurological, and cardiovascular effects. Analysis of reports from the US Food and Drug Administration Adverse Event Reporting System identified the most common adverse events as dissociation, sedation, and increased blood pressure. Network toxicology analysis suggested that esketamine may interact with multiple biological targets and pathways, potentially explaining its toxicological mechanisms. The findings indicate that while esketamine is effective, careful monitoring for specific adverse events is warranted.

DOI: 10.1007/s00210-026-05108-z