Entheogen: an evolutionary medicine for neuropsychiatric disorders.
Natl Sci Rev April 25, 2025 Yibo Wang, Xiaohui Wang 2 citations
The article proposes that entheogens—plant-based psychoactive substances used historically in spiritual and healing rituals—may be understood through the lens of evolutionary medicine as treatments for neuropsychiatric disorders. It argues that these compounds can address deep-seated brain mechanisms underlying conditions like depression and anxiety by resetting maladaptive neural pathways and promoting psychological flexibility. The text suggests that modern mental health challenges arise partly from mismatches between ancestral environments and contemporary lifestyles, and that entheogens offer a novel paradigm for healing by reconnecting individuals with evolved neurobiological processes. The authors indicate that this evolutionary perspective could guide clinical use and improve well-being.