Epilepsy & behavior reports
January 1, 2022
William B Barr, Anli Liu, Casey Laduke et al.
2 citations
A 75-year-old man with epilepsy experienced a progressive decline in cognition and behavior after a religious conversion 15 years earlier. He later developed severe religious delusions and Capgras syndrome. Brain imaging showed bilateral posterior cortical atrophy, chronic right parieto-occipital encephalomalacia, and right mesial temporal sclerosis. Electroencephalograms and neuropsychological testing indicated initial right temporal lobe abnormalities, followed by progressive frontal and bilateral dysfunction. The case suggests that a history of seizures, combined with sensory deprivation and progressive impairment of right posterior and bilateral anterior brain function, may have contributed to the religious conversion, which was followed by dementia and delusions with religious content.
Epilepsy & behavior reports
September 1, 2025
Laith Haddad, Samah Trad, Lama Charafeddine et al.
Neonatal glycine encephalopathy, a rare genetic disorder causing severe seizures, was successfully treated with a combination of intravenous ketamine, oral dextromethorphan, and sodium benzoate in a newborn. The patient's status epilepticus resolved, and developmental improvement was observed on follow-up. Intravenous ketamine use in neonates is rare, with only two prior cases reported. This is the first report of efficacy using this triple therapy, suggesting a potential intervention for managing intractable seizures in glycine encephalopathy.
Epilepsy & behavior reports
January 1, 2024
Edgar Matringe, Juan R Vidal, Marcela Perrone-Bertolotti et al.
An adolescent with juvenile myoclonic epilepsy experienced brief, involuntary urges to touch her forehead, triggered by a strange sensation inside her head. Video-EEG recordings showed these movements always followed diffuse generalized spike-and-wave bursts (GSWBs) lasting one to three seconds. The patient described the sensation as a "blip on a screen," suggesting she could detect the impact of the GSWBs on her stream of consciousness. This case supports the idea that some patients perceive their own EEG discharges, echoing the "blip syndrome" described by neurologist James W. Lance thirty years ago, and contributes to debates about the cognitive effects of interictal discharges.