Microdosing for drug delivery application—A review
Sensors and Actuators A Physical May 11, 2021 Agnes Beate Bußmann, Lorenz Maximilian Grünerbel, Claudia Patricia Durasiewicz et al. 53 citations
Microfluidic actuators, especially micropumps, could improve drug dosing by reducing size and energy consumption, yet they have not been widely adopted in industry. This work examines the limitations by analyzing safety requirements (preventing freeflow and backflow), dosing precision and stability, and system constraints like size, weight, power, and cost. It evaluates various mechanical micropumps and actuation mechanisms for drug delivery, highlights commercially available or near-market industrial microdosing systems, and summarizes technical solutions that meet fluidic performance, safety, and medical dosing requirements.