Acute ketamine connectivity changes in patients with major depression
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition September 16, 2025 Jen Evans, Carlos Zarate
Ketamine, a rapid-acting antidepressant, changes functional connectivity in the brain in ways that correlate with the density of receptors known to be involved in depression. In a double-blind placebo-controlled trial, participants received an infusion of ketamine or placebo while undergoing resting-state fMRI. The resulting connectivity changes matched several receptor types linked to depression. This method may help evaluate how new drugs affect the brain.