USO TERAPÊUTICO DA PSILOCIBINA: REVISÃO INTEGRATIVA
Revista fisio&terapia. October 8, 2025 Maurício Pedro Luciano da Costa, Pedro Bruschi Peiretti, Pedro Vinicius Rodrigues Silveira Silva et al.
A resurgence of scientific and clinical interest in psychedelic-assisted therapies, particularly with psilocybin, has been observed. This integrative literature review identifies promising therapeutic effects for treatment-resistant conditions such as depression, anxiety, substance dependence (alcohol and tobacco), and in palliative care for terminally ill patients. The central mechanism of action involves agonism of serotonergic 5-HT2A receptors, inducing altered states of consciousness that, when combined with psychotherapy, foster neural plasticity and promote lasting therapeutic insights. Despite this potential, methodological gaps were identified, including a scarcity of randomized controlled trials and long-term studies, reflecting the recent revival of interest after decades of prohibition. The review concludes that psilocybin has significant therapeutic potential but requires rigorous ethical regulation, professional training, and equitable access policies.