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Ryan J Mclaughlin

2 papers in the library · publishing 2025-2026

Papers

Mapping the acute effects of cannabis on multiple memory domains: A randomized, double-blind, placebo-controlled study.

Journal of psychopharmacology (Oxford, England) March 1, 2026 Carrie Cuttler, Ryan J Mclaughlin

Acute cannabis use broadly impairs multiple memory domains, not just verbal memory. In a randomized, double-blind, placebo-controlled trial, 120 cannabis users vaporized flower containing 0 mg, 20 mg, or 40 mg THC before completing memory tests. Cannabis increased false memories and harmed verbal memory (immediate, delayed, working), visuospatial memory (immediate, delayed), event-cued prospective memory, source memory, and temporal order memory. No significant differences emerged between the moderate and high doses. This is the first study to detect acute cannabis effects on prospective and temporal order memory, domains that better reflect everyday functioning.

DOI: 10.1177/02698811261416079 Full text THC Cannabis False memory Prospective memory +2

Cannabis produces acute hyperphagia in humans and rodents via increased reward valuation for, and motivation to, acquire food.

Proceedings of the National Academy of Sciences of the United States of America December 30, 2025 Catherine Hume, Carrie Cuttler, Samantha L Baglot et al.

Cannabis vapor inhalation acutely increases food intake in both humans and rats, an effect driven by central cannabinoid 1 receptors. In humans, energy intake rose within the first 30 minutes of snack access, regardless of dose or gender, without altering the proportion of macronutrients consumed. In rats, cannabis vapor reduced the time to start eating and increased the number of feeding bouts, overriding homeostatic appetite regulation by boosting motivation to eat and reducing food reward devaluation. These feeding effects were not accompanied by changes in circulating appetite-associated hormones, and they depended on central, not peripheral, CB1 receptors.

DOI: 10.1073/pnas.2518863122 Full text Cannabis Appetite Macronutrients Motivation +1