Four patients with post-COVID syndrome and chronic fatigue syndrome were treated with a combination of low-frequency repetitive transcranial magnetic stimulation and ketamine intravenous infusion over two to three weeks. Three patients experienced significant improvement. The authors indicate further research is needed.
A multimodal therapy combining ketamine-assisted psychotherapy, repetitive transcranial magnetic stimulation, neurofeedback, and additional psychotherapy sessions substantially reduced depressive symptoms in a Spanish clinic. Among 67 patients with various diagnoses who were screened for depression, Beck Depression Inventory-II scores dropped significantly from before to after treatment, with a large effect size. Exploratory follow-up of 28 patients indicated that improvements could be sustained for months or even years. The findings suggest that integrating multiple biological and psychological interventions may offer an effective approach for treating depression in a clinical setting.