A mixed methods Delphi study combined questionnaires and interviews with 37 providers and content experts to develop quality and safety indicators for psilocybin therapy. The qualitative component allowed participants to suggest new safety dimensions beyond the initial scope, improve indicator wording, and provide contextual explanations for decisions. This approach shows that qualitative methods can enhance Delphi studies beyond quantitative ratings alone.
MDMA is being studied as a treatment for PTSD, but many patients already take antidepressants. This retrospective case-control study used a national drug-death database to examine whether antidepressant use is linked to MDMA-related deaths. Among 1328 MDMA-positive deaths and 5312 matched controls, post-mortem detection of antidepressants was associated with lower odds of MDMA fatality compared to other drug-related deaths (adjusted odds ratio 0.595, 95% CI 0.491-0.722). However, when analyzing prescribed antidepressants, no significant association was found (adjusted odds ratio 0.838, 95% CI 0.688-1.021). The findings suggest an inverse association between antidepressant use and MDMA fatality, but the relationship is not straightforward.