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Gin S. Malhi

2 papers in the library · 346 citations · publishing 2007-2020

Papers

The psychological and neurophysiological concomitants of mindfulness forms of meditation

Acta Neuropsychiatrica April 1, 2007 Belinda Ivanovski, Gin S. Malhi 282 citations

A review of psychological and neurophysiological research on mindfulness meditation finds that mindfulness-based therapeutic interventions appear effective for depression, anxiety, psychosis, borderline personality disorder, and suicidal or self-harm behavior. Mindfulness meditation alone reduces substance use and recidivism in incarcerated populations, but its direct effectiveness for psychiatric disorders has not been specifically investigated. Electroencephalography research shows increased alpha, theta, and beta activity in frontal and posterior regions, with some gamma band effects, and theta activity strongly relates to meditation experience, though findings are inconsistent. Few neuroimaging studies suggest volumetric and functional changes in key brain regions, indicating a promising avenue for future research.

The effectiveness of ketamine on anxiety, irritability, and agitation: Implications for treating mixed features in adults with major depressive or bipolar disorder

Bipolar Disorders May 14, 2020 Roger S. McIntyre, Orly Lipsitz, Nelson B. Rodrigues et al. 64 citations

Intravenous ketamine reduces anxiety, irritability, agitation, and suicidal thoughts in adults with treatment-resistant major depressive disorder or bipolar disorder. In a retrospective analysis of 201 patients at a community clinic, those with elevated anxiety, irritability, and agitation showed significantly greater improvements in overall depressive symptoms, suicidal ideation, anxiety, irritability, and agitation compared to those without these features, regardless of the number of treatments. The findings suggest IV ketamine may be a rapid treatment option for mood disorder patients with mixed features.