Intravenous self-injection of four novel phenethylamines in baboons
Behavioural Pharmacology August 1, 1996 Christine A. Sannerud, B. Kaminski, Roland R. Griffiths 9 citations
Intravenous self-administration of four substituted phenethylamines was evaluated in baboons trained to self-inject cocaine. High doses of MDE and N-OH-MDA maintained self-injection, while NNDMA did not reliably do so, and BDMPEA maintained self-injection in each of three baboons at one or more doses. Intermediate to high doses of all four compounds decreased food pellet intake. In some baboons, high doses of N-OH-MDA, NNDMA, and BDMPEA produced signs of behavioral toxicity similar to those of classic psychomotor stimulants, though severity and profile differed between compounds. The study documents both similarities and differences in the behavioral profiles of these phenethylamines.