A new thin-layer chromatography (TLC) system was developed to separate and identify lysergide (LSD) from other related alkaloids. The system uses a silica gel adsorbent and a specific solvent mixture to achieve clear, reproducible separation. The method is designed for forensic and analytical chemistry applications, providing a reliable way to detect LSD in samples. The authors describe the preparation, development, and visualization of the chromatograms, noting that the system effectively distinguishes LSD from other ergot alkaloids. This technique offers a practical tool for drug analysis in laboratory settings.
A new hallucinogenic drug circulating under the name "STP" was identified as 2,5-dimethoxy-4-methylamphetamine (DOM). The drug was extracted from a tablet and characterized using high-resolution mass spectrometry, NMR, ultraviolet and infrared spectroscopy, and chromatography. The compound exhibited two distinct solid forms (polymorphs) that were studied by X-ray diffraction and differential scanning calorimetry. Animal behavioral tests showed its psychotomimetic activity is comparable to mescaline but up to 50 times more potent.