A Review of Treatment Modalities for Comorbid Neuropathic Pain and Depression.
Journal of integrative neuroscience May 26, 2025 Zhusheng Chen, Tong Cheng, Haorui Yang et al. 5 citations
Several treatment options for neuropathic pain and depression, especially when they occur together, are reviewed. Physiotherapy approaches like electroacupuncture and repetitive transcranial magnetic stimulation alter neuronal function. Pharmacological treatments include tricyclic antidepressants, gabapentin, ketamine, minocycline, and Chinese medicine, which work by modifying ion channels, neurotransmitter release, or inflammation. The review discusses the mechanisms and limitations of these therapies, aiming to guide future research and improve care for this common comorbidity.