Akihiro Miki

2 papers in the library · 4 citations · publishing 2006-2007

Papers

Urinary Excretion Profiles of 5-Methoxy-N,N-diisopropyltryptamine and Its Relevant Metabolites in Humans

JOURNAL OF HEALTH SCIENCE January 1, 2007 Tooru Kamata, Munehiro Katagi, Hiroe Kamata et al. 4 citations

In urine from six users of the psychedelic tryptamine 5-MeO-DIPT, three metabolites—5-OH-DIPT, 6-OH-5-MeO-DIPT, and 5-MeO-NIPT—were identified. Using enzymatic hydrolysis with ascorbic acid to prevent degradation, conjugated forms (sulfates and glucuronides) of the hydroxylated metabolites were fully cleaved, greatly increasing their detection, especially for 6-OH-5-MeO-DIPT. After hydrolysis, concentrations of 5-OH-DIPT ranged from 0.01 to 47 μg/ml and 6-OH-5-MeO-DIPT up to 69 μg/ml, while the parent drug and 5-MeO-NIPT remained below 1.7 and 3.5 μg/ml, respectively. Metabolites were detectable longer than the parent compound: 5-OH-DIPT up to 80 hours, 6-OH-5-MeO-DIPT and 5-MeO-NIPT up to 60 hours, versus 35 hours for 5-MeO-DIPT.

DOI: 10.1248/jhs.53.585 Chromatography Hydrolysis Urine Biochemistry

Metabolism of the psychotomimetic tryptamine derivative 5-methoxy-N,N-diisopropyltryptamine in humans: identification and quantification of its urinary metabolites.

Drug metabolism and disposition: the biological fate of chemicals February 1, 2006 Tooru Kamata, Munehiro Katagi, Hiroe T Kamata et al.

The body breaks down the psychedelic drug 5-MeO-DIPT (also known as 'Foxy') through three main pathways: removal of a methyl group to form 5-OH-DIPT, which is then often conjugated; direct addition of a hydroxyl group to the ring, sometimes followed by methylation, producing 6-OH-5-MeO-DIPT; and removal of an isopropyl group to form 5-MeO-NIPT. The first two metabolites are more abundant than the third. The parent drug can still be detected in urine up to 35 hours after use, but no N-oxide form was found.

DOI: 10.1124/dmd.105.005835 Full text