Anna Górska

2 papers in the library · 36 citations · publishing 2014-2016

Papers

The Role of Adenosine A1 and A2A Receptors in the Caffeine Effect on MDMA-Induced DA and 5-HT Release in the Mouse Striatum

Neurotoxicity Research November 13, 2014 Anna Górska, Krystyna Gołembiowska 36 citations

Caffeine worsens the increase in dopamine and serotonin release caused by MDMA (ecstasy) in the mouse striatum. Blocking adenosine A1 or A2A receptors with selective antagonists mimics caffeine's effect, with the A2A antagonist being more potent. This suggests that caffeine exacerbates MDMA's neurochemical effects and potential toxicity through adenosine receptor blockade, not through monoamine oxidase inhibition.

DOI: 10.1007/s12640-014-9501-0 Full text MDMA Serotonin Caffeine Neurochemistry +8

Effect of Some Psychoactive Drugs Used as ‘Legal Highs’ on Brain Neurotransmitters

Neurotoxicity Research April 1, 2016 Krystyna Gołembiowska, Alexandra Jurczak, Katarzyna Kamińska et al.

New psychoactive designer drugs like PMA, PMMA, and mephedrone, which are used as substitutes in ecstasy pills, increase the release of dopamine and serotonin in rat brain regions including the striatum, nucleus accumbens, and frontal cortex, similar to MDMA. The drugs also altered tissue levels of these neurotransmitters in region-specific ways: for example, mephedrone and PMMA increased dopamine in the striatum, while mephedrone and PMMA decreased dopamine in the frontal cortex. These changes suggest the drugs may have dependence potential, though further research is needed to assess neurotoxicity and abuse risk.

DOI: 10.1007/s12640-015-9569-1 Full text MDMA 5-HT Mephedrone Pma +3