Therapeutic Potential of Psychedelics: Mechanisms, Applications, and Challenges
Pharmaceutical science. August 27, 2025 Guilllermo Castaño-perez, Sara Isabel Castaño-ocampo
Psilocybin shows efficacy in treatment-resistant depression and cancer-associated anxiety, while MDMA combined with psychotherapy shows promise for post-traumatic stress disorder. For addictions, psilocybin is effective for alcohol use disorder and nicotine dependence, and ayahuasca shows potential for various substance use disorders. The evidence on efficacy, safety, and limitations of psychedelics like psilocybin, MDMA, LSD, and ayahuasca as monotherapy or in combination with assisted therapies is reviewed.