A Delphi consensus study with 89 experts from 17 countries identified 30 extra-pharmacological variables that are important or very important for reporting the setting in psychedelic clinical trials. These variables, forming the ReSPCT guidelines, cover physical environment, dosing session procedure, therapeutic framework and protocol, and subjective experiences. The findings reveal significant ambiguities in current conceptualizations of set and setting. The guidelines provide a new standard for designing and documenting contextual factors in psychedelic research.
Psychedelic medicine is experiencing a resurgence of interest after decades of dormancy, primarily driven by medical researchers. Recent legal changes in Canada have permitted some access to these compounds, though the abstract does not specify a main finding or argument beyond describing this renaissance and legal context.