Henrik Walter

2 papers in the library · 3 citations · publishing 2023-2026

Papers

Predictors of therapeutic response to psychedelic-assisted therapy: A systematic review.

Journal of psychopharmacology (Oxford, England) May 1, 2026 Grace Viljoen, Henrik Walter, Antonia Bendau et al. 3 citations

A systematic review of 54 studies found that the intensity of the acute psychedelic experience, particularly mystical-type experiences, is the most frequently reported predictor of therapeutic response in psychedelic-assisted therapy for mental disorders, though this was not consistent across all disorders or time points. Factors related to set, setting, and dose were associated with the likelihood and intensity of these experiences. The review included adult populations with substance-use disorders, major depressive disorder, anxiety disorders, obsessive-compulsive disorder, post-traumatic stress disorder, and existential distress, as well as naturalistic samples.

DOI: 10.1177/02698811251389581 Full text Depression Psilocybin Addictive disorders Psychedelics +1

Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Psychological medicine April 1, 2023 Laurent Elkrief, Bochao Lin, Mattia Marchi et al.

Cannabis use at age 16 is associated with psychotic-like experiences (PLEs) even after accounting for genetic risk for schizophrenia, according to an analysis of 1740 European adolescents from the IMAGEN cohort and replicated in 1223 individuals from a Dutch cohort. Polygenic risk scores for schizophrenia predicted both cannabis use and PLEs, and cannabis use remained a significant predictor of PLEs in models including genetic risk. However, no evidence was found that genetic risk mediates or moderates the cannabis–psychosis link. The findings suggest cannabis use is a risk factor for PLEs independent of genetic vulnerability to schizophrenia.

DOI: 10.1017/s0033291721003378 Full text Cannabis Polygenic risk score Psychosis risk Psychotic-like experience