Individuals with panic disorder (PD) and high anxiety sensitivity (AS) may experience increased anxiety when practicing mindfulness. Analyzing data from 1,521 Japanese participants, the study revealed that heightened AS significantly influenced how individuals observed internal sensations, with higher AS linked to greater internal observation but lower external observation. PD also predicted mindfulness observation but was less impactful than AS. These findings underscore the importance of tailoring mindfulness interventions to address specific anxiety sensitivities, enhancing their effectiveness for those struggling with anxiety-related issues.
Patients with treatment-resistant depression whose symptoms are loosely connected before ketamine therapy are more likely to respond than those with tightly linked symptoms. Among 447 patients receiving intravenous ketamine or intranasal eskatamine, non-responders had denser pre-treatment symptom networks (global strength 4.03) compared with responders (global strength 1.06). After treatment, responders' network strength increased, while non-responders' decreased. Sparse baseline symptom networks may indicate greater capacity for reorganization, making pre-treatment network density a potential marker of ketamine response.