The lancet. Psychiatry
January 1, 2025
Carolina Seybert, Nina Schimmers, Lucio Silva et al.
26 citations
Reporting on the psychological intervention component of psychedelic-assisted psychotherapy is mostly incomplete and inconsistent across studies, limiting replicability and clinical translation. A systematic review of 45 original studies on psilocybin, MDMA, LSD, or ayahuasca for mental disorders found that descriptions of psychotherapy varied widely and completeness of information was generally low, based on an adapted Template for Intervention Description and Replication checklist. Studies involving MDMA showed more homogeneous psychotherapy and more procedural details. Improved reporting on psychological interventions would support replicability, generalisability, and accurate interpretation of research, as well as enhance feasibility and safety of future clinical research and real-world implementation.
Nature Medicine
June 14, 2023
Carolina Seybert, Gonçalo Cotovio, Luís Madeira et al.
24 citations
No Summary
Brain stimulation
October 5, 2021
Gonçalo Cotovio, Albino J. Oliveira‐maia, Carter Paul et al.
3 citations
Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex does not reduce depressive symptoms more than sham stimulation in patients with treatment-resistant depression. In a randomized controlled trial, both active and sham tDCS groups showed similar improvements in depression scores over six weeks, with no significant difference between them. The findings suggest that tDCS, as administered in this protocol, is not effective as a standalone treatment for this population.
Psychedelics
June 28, 2026
Joost J. Breeksema, Ulf Bremberg, Jens H. van Dalfsen et al.
Psychedelic therapies face layered complexity from interactions between pharmacological and extra-pharmacological factors, and their embeddedness in societal, legal, and regulatory systems. This is compounded by epistemic fragmentation: dominant biomedical paradigms often clash with knowledge from social sciences, humanities, or Indigenous traditions. Though interdisciplinary engagement is increasingly recognized as necessary, existing calls rarely specify structural or pedagogical conditions for operationalizing it. Addressing these complexities requires moving beyond superficial collaboration; genuine interdisciplinary progress needs researchers capable of productive friction across epistemic cultures. The authors propose cultivating T-shaped competencies and intersectoral training as a structural response to these systemic challenges.
Revista Portuguesa de Psiquiatria e Saúde Mental
September 8, 2021
Gonçalo Cotovio, Ana Maia, Ana Velosa et al.
No Summary