People who use psychedelics in natural settings show weaker increases in alpha and beta brainwave power when thinking about themselves, compared to non-users, especially in regions like the posterior cingulate cortex that handle self-related information and memory. However, these differences were not replicated in a second, smaller dataset, limiting confidence in the finding. The results contribute to ongoing debate about how long psychedelic effects last in brain circuits linked to self-processing and question the specific role of default-mode network hubs in such changes.
People who have used psychedelics in naturalistic settings show weaker increases in alpha and beta brain-wave power during self-related thoughts compared to non-users, particularly in regions linked to self-processing and memory. This pattern appeared in one dataset of 70 participants but was not replicated in a second dataset of 38 participants, possibly due to the smaller sample and spatial resolution limits. The non-replicability restricts interpretation, but the work adds to understanding how psychedelic use relates to self-related thoughts and well-being, important for assessing mental health impacts.