British journal of pharmacology
April 1, 1986
L Rényi
39 citations
In rats, the ejaculatory response and other behaviors linked to serotonin (5-HT) were tested after giving a serotonin-releasing drug (5-MeODMT) following treatment with various serotonin reuptake inhibitors (fluoxetine, zimeldine, alaproclate, citalopram). Acute doses of fluoxetine and zimeldine reduced the ejaculatory response when given 48 hours before 5-MeODMT, an effect blocked by a serotonin receptor antagonist. After 7 or 14 days, a single dose of fluoxetine enhanced the response, which returned to normal by day 24. Repeated fluoxetine treatment extended the blockade and delayed sensitization. Alaproclate and citalopram only blocked the response 1 hour after acute dosing. The findings indicate that different serotonin reuptake inhibitors do not uniformly alter serotonin receptor functions.
British journal of pharmacology
August 1, 1986
L Rényi
10 citations
Repeated but not single treatment with the 5-HT agonist 5-MeODMT strongly but reversibly reduced the ejaculatory response and other behavioral responses in rats. Repeated treatment with nonselective, irreversible MAO inhibitors nialamide and pargyline markedly reduced the ejaculatory response but only slightly affected behavioral responses. Repeated treatment with MAO-B inhibitor (-)-deprenyl, MAO-A inhibitor clorgyline, reversible MAO-A inhibitor moclobemide, and low doses of PCA did not affect either response. Combined repeated treatment with clorgyline plus PCA caused an almost complete blockade of all responses. Selective, reversible MAO-A inhibitors amiflamine, alpha-ethyltryptamine, and alpha-methyltryptamine reduced the ejaculatory response after both single and repeated treatments, with behavioral responses blocked only after repeated treatment. The authors conclude that single and repeated treatments with different MAO inhibitors do not produce a common alteration in 5-HT2 receptor functions.
The Journal of pharmacy and pharmacology
September 1, 1985
T Archer, B Tandberg, L Rényi et al.
8 citations
Repeated administration of drugs that increase tryptaminergic neurotransmission blocked the effects of an acute injection of 5-MeODMT on postdecapitation convulsions in rats. Zimelidine, fluoxetine, amiflamine, and alpha-ethyltryptamine given orally over 10 days substantially blocked the increase in latency and duration of convulsions caused by 5-MeODMT, while alaproclate, clorgyline, and pargyline caused a lesser blockade. Repeated 5-MeODMT administration completely blocked the acute effects. These findings suggest down-regulation of serotonin receptors mediating the convulsion response and offer a simple model for studying receptor sensitivity changes at the spinal level.