Effect of intravenous esketamine in emergency cesarean deliveries: a retrospective analysis of maternal and neonatal outcomes.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians December 1, 2024 Xiao-Mei Huang, Hong-Xia Qiu 3 citations
In pregnant women undergoing emergency cesarean section under epidural anesthesia, a single intravenous dose of 0.25 mg/kg esketamine given between incision and delivery is associated with stable maternal and neonatal outcomes. Compared to a control group, the esketamine group showed higher systolic and diastolic blood pressure at 5 and 10 minutes after administration, along with increased rates of arrhythmias, dizziness, and nystagmus during surgery, but a lower incidence of hypotension. After surgery, nausea and dizziness were more common. For newborns, there were no differences in gender, weight, Apgar scores, or need for intensive care, though umbilical artery pH was slightly higher in the esketamine group. The authors suggest the dose is safe for both mother and baby.