Behavioral pharmacology of sigma-ligands.
Pharmacopsychiatry November 1, 2004 G Skuza, K Wedzony
Sigma receptors are unique brain binding sites distinct from opioid and PCP receptors, classified into sigma-1 and sigma-2 subtypes, with sigma-1 recently cloned. They modulate neurotransmitter systems including noradrenergic, glutamatergic, and dopaminergic pathways. Initially linked to psychotic disorders, they are now implicated in motor disorders, psychotic disorders, and neuroprotective mechanisms. Recent development of high-affinity, selective sigma ligands has enabled investigation of their therapeutic potential. This review summarizes behavioral effects of sigma receptor ligands in animal models related to schizophrenia and affective disorders.