The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non‐clinical sample
Progress in Neuro-psychopharmacology and Biological Psychiatry March 1, 2019 J. Soler, B. Arias, J. Moya et al.
Both the ZNF804A gene and cannabis use are risk factors for psychosis, and this study examined their relationship with schizotypal personality traits in 385 healthy Spanish adults. People with the AA genotype of the rs1344706 variant scored higher on interpersonal schizotypy. An interaction between the AA genotype and lifetime cannabis use was found for cognitive-perceptual schizotypy, showing a dose-effect pattern: among AA carriers, schizotypy scores increased with more frequent cannabis use, from sporadic to intense use. These results suggest that cannabis use may modulate the effect of ZNF804A on psychosis proneness.