The effects of cannabinoid agonism on auditory discrimination.
Behavioural pharmacology April 1, 2025 Danielle Nykanen, Hannah Stiffler, Merrick Bay et al.
Cannabinoid agonism via WIN 55,212-2 did not impair auditory discrimination in rats. Twenty-two rats were trained to press a lever for sucrose in response to either a pure tone or white noise, with correct responses reinforced and incorrect ones punished. After reaching criterion, they received 1.2 mg/kg, 3 mg/kg, or saline. On day 3, active lever-pressing was higher in both dose groups compared to saline, but overall pressing decreased over time in the high-dose group. No effects on discrimination or errors were observed, indicating that cannabinoid agonism did not negatively affect auditory discrimination, contrary to some previous findings.