Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.
British journal of pharmacology August 1, 1990 L I Backus, T Sharp, D G Grahame-Smith
Blocking 5-HT2 receptors with antagonists such as ritanserin, ICI 170,809, or low-dose ketanserin enhances the behavioral syndrome caused by 5-HT1A receptor activation in rats, suggesting that 5-HT2 receptors normally inhibit 5-HT1A-mediated responses. Higher doses of ketanserin reduce the syndrome, likely due to additional alpha1-adrenoceptor blockade. The enhancement is not due to general behavioral activation, as the antagonists do not affect apomorphine-induced stereotypy or hyperactivity. These findings indicate a regulatory interaction between 5-HT2 and 5-HT1A receptor systems.