Ketamine: A Review for Clinicians
FOCUS The Journal of Lifelong Learning in Psychiatry July 1, 2018 Gerard Sanacora, Rachel Katz 16 citations
Ketamine, originally used as an anesthetic, shows promise as a rapid-acting treatment for severe depression, including treatment-refractory cases. A single dose provides short-lived relief, but multiple infusions may offer sustained effects. Its quick onset could help prevent hospital stays, treat acute suicidal ideation, and facilitate medication changes. Combining ketamine with psychotherapy may enhance response and duration. Despite growing use for various psychiatric disorders, there is inadequate data on true clinical efficacy, safety, and mechanisms of action. This article reviews ketamine's history as an antidepressant, current hypotheses on its mechanisms, and existing evidence on safety and efficacy for clinicians.