Predictive value of heart rate in treatment of major depression with ketamine in two controlled trials
Clinical Neurophysiology March 14, 2021 Torsten M. Meyer, Martin Brunovský, Jiřı́ Horáček et al. 25 citations
In patients with major depressive disorder, heart rate and heart rate variability measured before and during ketamine infusion can predict who will respond to treatment. Among 51 patients, those who responded to ketamine had a higher heart rate throughout the study, including at baseline, compared to non-responders. Ketamine infusion increased both heart rate and heart rate variability power during and after infusion. Heart rate and heart rate variability power, but not normalized frequency bands, discriminated between responders and non-responders. These findings suggest that autonomic nervous system markers may help optimize treatment selection for major depressive disorder.