Case report: Successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach
Addiction Science & Clinical Practice January 19, 2020 Jennifer Rozylo, Keren Mitchell, Mohammadali Nikoo et al.
A high-risk patient with opioid use disorder who had previously failed buprenorphine/naloxone induction due to withdrawal symptoms was successfully started on a therapeutic dose using a microdosing regimen combined with assertive outreach. The team gradually increased the dose without causing withdrawal, and the patient continued consistent medication use for four weeks, gradually reducing illicit substance use. The case suggests that microdosing can minimize barriers to buprenorphine/naloxone induction and supports the need for larger studies.