Buprenorphine 'microdosing' method for switching patients with opioid dependence from methadone to buprenorphine.
BMJ case reports November 7, 2024 Yesh Chandra Singh, Shalini Singh, Roshan Bhad et al.
Transitioning from methadone to buprenorphine for opioid agonist treatment can be limited by factors like withdrawal symptoms and lengthy tapering. A novel approach called microdosing, or the Bernese method, offers a faster alternative. Two cases are described in which patients successfully switched from methadone to buprenorphine using this method, suggesting it may be a valuable option for those who cannot tolerate the classical gradual taper.