Effects of cannabidiol in cannabis flower: Implications for harm reduction.
Addiction biology January 1, 2022 Laurel P Gibson, Hollis C Karoly, Jarrod M Ellingson et al.
Cannabis flower with both THC and CBD produces similar positive effects but less paranoia and anxiety than THC-dominant cannabis. In a naturalistic at-home study, 159 regular cannabis users were randomly assigned to one of three chemovars: THC-dominant (24% THC, 1% CBD), THC+CBD (9% THC, 10% CBD), or CBD-dominant (1% THC, 23% CBD). Plasma samples showed those using the CBD-dominant or THC+CBD chemovars had significantly less THC and more CBD than those using the THC-dominant chemovar. The THC+CBD chemovar yielded similar positive subjective effects but significantly less paranoia and anxiety compared to the THC-dominant chemovar, suggesting potential harm reduction from CBD.