Hallucinogen-Tranquilizer Interaction: Its Nature
Science May 2, 1969 Michael F. Halasz, Jaroslav Formanek, Amedeo S. Marrazzi
The interaction between hallucinogens and tranquilizers at cerebral synapses and in animal behavior follows a competitive inhibitory pattern. As the tranquilizer dose increases, its effect shifts from protecting against hallucinogen effects to dominating and increasing tranquilizer toxicity. Behavioral data from cats and monkeys, along with rats, show that a sufficiently high tranquilizer dose can aggravate rather than protect, consistent with a competitive mechanism.