Sigma receptors mediated the psychotomimetic effects of N-allylnormetazocine (SKF-10,047), but not its opioid agonistic-antagonistic properties.
Neuropharmacology August 1, 1984 N Khazan, G A Young, E E El-Fakany et al.
The prototype sigma agonist SKF-10,047 has opioid properties in its (-) isomer and psychotogenic properties in both its (+) and (-) isomers, similar to PCP. (-)-SKF-10,047 blocked EEG and behavioral effects of morphine in naive rats, precipitated withdrawal in morphine-dependent rats, produced physical dependence shown by naloxone-induced withdrawal, and displaced [3H]dihydromorphine from brain homogenates. (+)-SKF-10,047 did not produce dependence or displace [3H]dihydromorphine. This dissociation suggests sigma receptors are linked to psychogenic effects, not opioid effects, which are likely mediated by mu or kappa receptors.