Phencyclidine receptors and N-methyl-D-aspartate antagonism: electrophysiologic data correlates with known behaviours.
Pharmacology, biochemistry, and behavior October 1, 1988 D Martin, D Lodge
A series of psychoactive phencyclidine (PCP) and sigma receptor ligands were compared for their ability to block NMDA receptors using cortical wedges and isolated frog spinal cords. Phencyclidine receptor ligands, but not sigma or kappa ligands, selectively antagonized NMDA on both preparations. Combination studies suggested that dissociative anaesthetics and sigma benzomorphans act at the same site. The relative potencies of the drugs as NMDA antagonists correlated well with their potency in PCP receptor binding studies in vitro and in PCP discrimination studies in vivo.